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Woman touching her skin | What is Collagen and What are Collagen Fibers | collagen supplements | Featured

What Is Collagen And What Are Collagen Fibers?

The terms “collagen fibers” and “collagen” are the buzzwords these days, but what are they? Discover one of the crucial proteins in the body in this post. RELATED: Microbiome And Mental Health — Do They Matter? In this article: What Is Collagen? Kinds of Connective Tissues and Extracellular Components How Does the Body Produce Collagen? Kinds of Collagen Fibers and Benefits of Collagen The Connection of Microbiome and Collagen Collagen Fibers: Dissecting Their Meaning and Purpose in the Body What Is Collagen? Many articles talk about “collagen fibers,” “collagen,” and “collagen peptides,” among others. They tend to use these terms interchangeably, so it makes you wonder whether they mean the same thing. To help you understand these terms and this entire post, let’s define each of them: Collagen – Collagen is one of the most abundant proteins in an extracellular matrix. We’ll identify the “extracellular matrix” later. Collagen Fibers – When collagen bundles together, they form...
Woman sitting sofa thinking | The Gut’s Impact On Our Brain And Behavior | Brain Microbiome | gut brain axis microbiome | Featured

The Gut’s Impact On Our Brain And Behavior | Brain Microbiome

Explore the intimate but complex relationship between the gut and brain microbiome in a comprehensive study below. RELATED: Big Fungus, Big Opportunity (Or How I Almost Missed the Product Idea Of A Lifetime) In this article: More Scientists Are Looking Into the Gut Microbiome and the Brain Gut Microbiome and Brain Link Gut-Brain Axis: How the Microbiome Influences Anxiety and Depression Leaky Gut and the Old Friend Hypothesis The Effects of Diet and Environment on Gut and Brain Microbiome Brain Microbiome: How Gut Microbiota Develops — and Challenges — the Human Brain More Scientists Are Looking Into the Gut Microbiome and the Brain Over the past few years, more scientists are digging deeper into the brain microbiome: What’s the relationship between gut flora and brain function, including behavior? This question is all due to the growing number of neurodegenerative diseases. These include Alzheimer’s disease (AD), multiple sclerosis (MS), and Parkinson’s disease. What is Parkinson’s disease? It is...
woman holding fork eating vegetables | Holistic Approach To Gut Health and Heal With Plants | holistic approach to gut health | Featured

Holistic Approach To Gut Health And Healing With Plants

You can achieve gut healing with plants and a holistic approach. These articles will provide you with all the information you need. RELATED: What Dr. G Eats In A Day In this article: Understanding Holistic Approach Holistic Approach to Gut Health Nutrition and Plants as Medicine Holistic Approach Helps Promote Better Gut Health and Healing Understanding Holistic Approach What is a holistic approach, and how is it beneficial to gut health? The following articles provide the answer: 1. Principles of Holistic Medicine What is holistic medicine? This article will help shed light. In summary, it is a type of healing that promotes complete wellness by acknowledging a person is a multifaceted being: You have your body besides your mind. You are also a spiritual person (and this doesn’t have to be about religion). To achieve optimal health, all these aspects—mind, body, and spirit—must be well. Everything should be in balance. The idea of the mind-body-spiritual connection isn’t new. The ancient...
Woman sitting on bed holding her stomach | Can A Nervous Stomach Affect The Entire Body? | The Gut Brain Axis | stomach pain and nausea | Featured

Can A Nervous Stomach Affect The Entire Body? | The Gut-Brain Axis

A nervous stomach can often make one feel uneasy, but does it have any real, fact-based, negative effects on the body? Read on to find out how symptoms of digestive problems such as an upset stomach, abdominal pain, and stomach cramps trigger anxiety. RELATED: BIOHM Launches The First Probiotic Engineered To Address the Key Role of Fungus In Digestive Health In this article: The Gut-Brain Relationship Gut Microbiota and Brain Interaction Behind the Nervous Stomach Anxiety Process Findings from the Study Review What Can You Do? The Connection Between Anxiety and a Nervous Stomach Some people start feeling nervous when they experience an upset stomach. The pain can make them confused, agitated, and generally unwell. Can nervous stomach symptoms really lead to anxiety? In a study review by the Hellenic Society of Gastroenterology, the researchers explored the correlation between digestive tract issues and stress. The Gut-Brain Relationship Researchers revealed that the gastrointestinal tract and brain have a...
Person pouring coke in glass | Gut Reset Diet: How To Restore Gut Health | how to reset your gut | Featured

Gut Reset Diet: How To Restore Gut Health

This gut reset diet plan will help you manage digestive issues and heal the gut after feasting over the holidays. RELATED: The 9 Best Foods To Eat When You’re Constipated, According to a Microbiome Scientist In this article: Kill the Bloat with Lemon and Warm Water Try Intermittent Fasting (IF) Take Probiotics and Prebiotics Consume Complex Carbs and Healthy Fats for Breakfast Consume Bone Broth More During a Gut Reset Diet Skip the Artificial Sweeteners and Processed Foods Reduce Your Stress While on a Gut Reset Diet Plan Gut Reset Diet Guide to Improve Digestion and Gut Health 1. Kill the Bloat with Lemon and Warm Water One of the best foods to include in your gut reset diet plan is lemon. This wonder fruit packed with lots of vitamin C is also excellent for digestive health. It can act as a diuretic. It can help flush out not only toxins but also excess water and...
man pressing bloated abdomen | Abdominal Bloat Symptoms And How To Prevent It | bloat symptoms | how to get rid of bloated stomach | Featured

Abdominal Bloat Symptoms And How To Prevent Them

On days or nights when you just can't get gas out of your system, here are nine ways to keep bloating symptoms at bay. RELATED: Your Diet & Inflammation — The Connection You Can Control In this article: What Is Bloating? 9 Ways to Prevent Bloat Symptoms and Get Rid of a Distended Stomach Common Bloat Symptoms and Effective Ways to Prevent Them What Is Bloating? Abdominal bloating is when the gastrointestinal tract (GI) gets filled with air or gas. This occurs when the body produces too much gas or swallows too much air. While a distended belly or bloated stomach pain won't lead to fatal complications, it can make one experience the following signs and symptoms: Abdominal pain Constipation Appetite loss Nausea Excessive burping Heartburn Chest tightness Rapid shallow breathing 9 Ways to Prevent Bloat Symptoms and Get Rid of a Distended Stomach 1. Portion Food Consumption Perhaps the simplest way to prevent your stomach from bloating is...
girl peeking behind dark chocolate | Why Eating Dark Chocolate Is Good For The Gut | leaky gut dark chocolate | chocolate and leaky gut | Featured

Why Eating Dark Chocolate Is Good For The Gut

Learn how you can relieve symptoms of leaky gut with dark chocolate and why this delectable treat is beneficial to your gut below. RELATED: How To Heal A Leaky Gut In 5 Simple Steps In this article: How Leaky Gut Happens Dark Chocolate Benefits Your Gut Microbes Need Dark Chocolate How Prebiotics Benefit Your Body What Kind of Chocolate Is Good for Your Gut Health? How Often Should You Consume Dark Chocolate? Dark Chocolate and Leaky Gut: Why They Go Well Together Click here to jump to the infographic. What Is Leaky Gut? Also called increased intestinal permeability (IP), leaky gut is a condition that increases the gap in the intestinal walls’ lining. Through these gaps, fungi, bacteria, food particles, and waste products can directly enter the bloodstream. How Leaky Gut Happens Normally, waste and food particles aren’t able to pass through gaps in the intestinal wall. If a person suffers from leaky gut syndrome, fungal and...
Man eating grilled meat | Best SIBO Diet: Foods We Need To Eat and Avoid | sibo specific diet | Featured

Best SIBO Diet: 9 Foods We Need To Eat And Avoid

Small intestinal bacterial overgrowth, or SIBO, is just like it sounds: your small intestine has a lot of bacteria in it. Check out our recommended SIBO diet food list below to find out what you need to eat versus avoid. RELATED: The 9 Best Foods To Eat When You’re Constipated, According to a Microbiome Scientist In this article: Recommended Diets for SIBO Foods to Eat in Your SIBO Diet Foods to Avoid in Your SIBO Diet Customizing Your SIBO Diet: 9 Foods to Eat and Avoid What is SIBO? SIBO is a digestive disorder that occurs when the small intestine has excessive bacteria. While it is essential to have bacteria in the gut to aid in digestion, too much of it can cause some complications. What is a SIBO Diet? This diet involves the elimination of bacteria-induced inflammation in the digestive tract, particularly in the small intestine. Carbs that are difficult to digest or...
Woman holding her stomach | Microbiome And Mental Health - Do They Matter? | microbiome mental health | Featured

Microbiome And Mental Health — Do They Matter?

Is there really a link between one’s microbiome and mental health, i.e., does gut health affect the brain? Find out in this article. RELATED: 5 Important Ways Gut Health Affects Your Mood Microbiome and Mental Health: Why It's Important for Your Sanity The Surprising Link Between the Gut Microbiome and Mental Health According to a study entitled The Neuroactive Potential of the Human Gut Microbiota in Quality of Life and Depression, gut bacteria can affect the state of one’s mental health. The initial findings, reported in the publication Nature Microbiology, have yet to undergo scrutinous reviews and human subject studies. However, it may open doors for an alternative, probiotic-based mental health treatments, i.e., gut health for mental health, once further validated. Gut Health and Mental Health: Results of the Study Researchers used GP records and medical tests to look for relationships between fecal microbes, life quality, and depression. The study involved over 1,000 people who were...
Gut balances keep you from losing weight

3 Ways Gut Imbalances Keep You from Losing Weight — and 7 Ways to...

We know… another thing that depends on our gut?! Yep, it’s true — a healthy, balanced gut acts as the solid foundation for successful weight loss. When your gut is imbalanced, you’ll have a hard time losing weight. Here are three reasons why.

How Do Interactions Between Gut Bacteria and Fungi Exacerbate Crohn’s Disease?

Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center researcher receives NIH funding to investigate Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, professor and director of the Center for Medical Mycology at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease. Now, to learn precisely how that fungus interacts with bacteria to trigger CD, Ghannoum has received a five-year, $3 million grant from the National Institutes of Health. His investigation will involve innovative molecular and cellular technologies, to delete specific genes in the fungus and note the effects on the inflammation that is a marker for CD using powerful microscopic analysis. “Uncovering how the...
Effects of a Novel Probiotic Combination on Pathogenic Bacterial-Fungal Polymicrobial Biofilms

Effects of a Novel Probiotic Combination on Pathogenic Bacterial-Fungal Polymicrobial Biofilms

Abstract: Dysbiosis of the gut microbiome has been implicated in inflammatory bowel diseases. We have shown that levels of Candida tropicalis, along with those of Escherichia coli and Serratia marcescens, are significantly elevated in Crohn’s disease (CD) patients. Here, we evaluated the ability of a novel probiotic to prevent and treat polymicrobial biofilms (PMB) formed by C. tropicalis with E. coli and S. marcescens. Since Candida albicans has been reported to be elevated in CD patients, we investigated the interactions of C. albicans with these bacterial species in biofilm formation. We determined whether the interaction between Candida spp. and bacteria is specific by using Trichosporon inkin and Saccharomyces fibuligera as comparators. Additionally, the effects of probiotics on C. albicans germination and biofilm formation were determined. To determine the ability of the probiotic to prevent or treat mature biofilms, probiotic filtrate was added to the PMB at early (prevention) and mature (treatment) phases. Biofilm thickness and architecture were assessed by confocal scanning laser microscopy....
2017 NIH-wide workshop report on “The Human Microbiome: Emerging Themes at the Horizon of the 21st Century”

2017 NIH-wide workshop report on “The Human Microbiome: Emerging Themes at the Horizon of...

Abstract: The National Institutes of Health (NIH) organized a three-day human microbiome research workshop, August 16–18, 2017, to highlight the accomplishments of the 10-year Human Microbiome Project program, the outcomes of the investments made by the 21 NIH institutes and Centers which now fund this area, and the technical challenges and knowledge gaps which will need to be addressed in order for this field to advance over the next 10 years. This report summarizes the key points in the talks, round table discussions, and Joint Agency Panel from this workshop. Download Full Paper:
The Gut Microbiome as a Major Regulator of the Gut-Skin Axis

The Gut Microbiome as a Major Regulator of the Gut-Skin Axis

Abstract: The adult intestine hosts a myriad of diverse bacterial species that reside mostly in the lower gut maintaining a symbiosis with the human habitat. In the current review, we describe the neoteric advancement in our comprehension of how the gut microbiota communicates with the skin as one of the main regulators in the gut-skin axis. We attempted to explore how this potential link affects skin differentiation and keratinization, its influence on modulating the cutaneous immune response in various diseases, and finally how to take advantage of this communication in the control of different skin conditions. Download Full Paper:
Dysbiosis in the oral bacterial and fungal microbiome of HIV-infected subjects is associated with clinical and immunologic variables of HIV infection

Dysbiosis in the oral bacterial and fungal microbiome of HIV-infected subjects is associated with...

Abstract: The effect of smoking on microbial dysbiosis and the potential consequence of such shift on markers of HIV disease is unknown. Here we assessed the relationship of microbial dysbiosis with smoking and markers of HIV disease. Download Full Paper:
The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease– Like Ileitis

The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–...

Abstract: Background: Epidemiological studies indicate that the use of artificial sweeteners doubles the risk for Crohn’s disease (CD). Herein, we experimentally quantified the impact of 6-week supplementation with a commercial sweetener (Splenda; ingredients sucralose maltodextrin, 1:99, w/w) on both the severity of CD-like ileitis and the intestinal microbiome alterations using SAMP1/YitFc (SAMP) mice. Methods: Metagenomic shotgun DNA sequencing was first used to characterize the microbiome of ileitis-prone SAMP mice. Then, 16S rRNA microbiome sequencing, quantitative polymerase chain reaction, fluorescent in situ hybridization (FISH), bacterial culture, stereomicroscopy, histology, and myeloperoxidase (MPO) activity analyses were then implemented to compare the microbiome and ileitis phenotype in SAMP with that of control ileitis-free AKR/J mice after Splenda supplementation. Results: Metagenomics indicated that SAMP mice have a gut microbial phenotype rich in Bacteroidetes, and experiments showed that Helicobacteraceae did not have an exacerbating effect on ileitis. Splenda did not increase the severity of stereomicroscopic/histological) ileitis; however, biochemically, ileal MPO activity was increased in SAMP...
The Mycobiome in HIV

The Mycobiome in HIV

Abstract: Purpose of Review—There are a limited number of studies investigating the association between the microbiome and HIV. Although the majority of these published investigations have focused on the role of the bacterial community (bacteriome) in this setting, a handful of studies have also characterized the role of the mycobiome in HIV-infected individuals. This review will summarize the most recent reports pertaining to the role of the fungal community in HIV. Recent findings—Differences in the composition of the oral and respiratory mycobiome in HIV-infected individuals compared to uninfected individuals have been reported. Summary—Our review shows that studies investigating the role of the mycobiome in the setting of HIV are severely lacking. With recent advances in our understanding of the composition of the human microbiome, investigations into the role of the bacteria and fungus comprising the overall microbiota and how the two interact to influence each other and the host is crucial. Download Full...
Bacteriome and mycobiome associations in oral tongue cancer

Bacteriome and mycobiome associations in oral tongue cancer

Abstract: Squamous cell carcinoma of the oral (mobile) tongue (OMTC), a non-human papilloma virus-associated oral cancer, is rapidly increasing without clear etiology. Poor oral hygiene has been associated with oral cancers, suggesting that oral bacteriome (bacterial community) and mycobiome (fungal community) could play a role. While the bacteriome is increasingly recognized as an active participant in health, the role of the mycobiome has not been studied in OMTC. Tissue DNA was extracted from 39 paired tumor and adjacent normal tissues from patients with OMTC. Microbiome profiling, principal coordinate, and dissimilarity index analyses showed bacterial diversity and richness, and fungal richness, were significantly reduced in tumor tissue (TT) compared to their matched non-tumor tissues (NTT, P<0.006). Firmicutes was the most abundant bacterial phylum, which was significantly increased in TT compared to NTT (48% vs. 40%, respectively; P=0.004). Abundance of Bacteroidetes and Fusobacteria were significantly decreased in TT compared to matched NTT...
The Mycobiome: Impact on Health and Disease States

The Mycobiome: Impact on Health and Disease States

Introduction: Research efforts by mycologists over the past few years finally established the fungal community and its previously overlooked members as crucial components of the microbiome. It is now undeniable that the commensal fungal microorganisms, alongside the other components of the microbiota, play a central role in association with the human host. Ongoing research is describing the fungal community and is providing new insights into biological mechanisms by which multidirectional interactions between the microbiome, their genomes (metagenome), metabolites (metabolome), and the human host ultimately affect health and/or disease states. Download Full Paper:
The mycobiome: Role in health and disease, and as a potentialprobiotic target in gastrointestinal disease

The mycobiome: Role in health and disease, and as a potentialprobiotic target in gastrointestinal...

Abstract: human gastrointestinal (GI) tract is home to trillions of microorganisms, some beneficial and otherspotentially harmful. Recent advances in science have allowed us to identify the multitude of organismsinhabiting the GI tract and parse out those that play a role in inflammatory bowel disease (IBD). Unfortu-nately, most research has focused on studying only the bacteria while ,overlooking a key player, fungus.In order to address this issue, we have focused our efforts on studying the fungal community in the GItract known as the mycobiome. We found that patients with Crohn’s disease (CD) tend to have muchhigher levels of the fungus Candida tropicalis compared to their healthy family members, as well as twobacteria, Escherichia coli and Serratia marcescens. Furthermore, we showed that these three organismsworked together to form robust biofilms capable of exacerbating intestinal inflammation. Herein, wediscuss the role of the mycobiome in health and disease, and highlight the importance of maintainingbalance...